Using SPME for Organic Compound Determination


The Environmental Protection Agency (EPA) has classified 1,4-Dioxane as a likely carcinogen that does not break down readily. Purge and trap concentration and liquid-liquid extraction are the most common techniques for the sampling of 1,4-Dioxane. Each of these techniques has its advantages and drawbacks. Accordingly, this application will explore Solid Phase Microextraction and organic compound determination as a possible option for the sampling of 1,4-Dioxane.

There are many complications when sampling 1,4-Dioxane. Therefore when sampling by purge and trap, a factor that can inhibit detection limits is the fact that 1,4-Dioxane has very poor purge efficiency. In order to counter this issue, many laboratories use a heated purge cycle and/or purge larger volumes of sample. Liquid-liquid extraction is an option for the extraction of 1,4-Dioxane out of water, however, the extraction solvent needs to be reduced or blown down in order to concentrate the analyte and in doing this, 1,4-Dioxane can be lost.

Solid Phase Microextraction (SPME) is a semi-exhaustive sampling technique that can be used to sample 1,4-Dioxane in water without the complications of purge efficiency or concentration of an extract. Therefore by selecting the optimum SPME fiber, 1,4-Dioxane can be extracted from a water sample and desorbed into the Gas Chromatograph/Mass Spectrometer (GC/MS) for compound detection. This application will examine both headspace and immersion SPME for the sampling and analysis of 1,4-Dioxane. 


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