Static Headspace Sampling with GC/FID
This application will demonstrate headspace for residual solvents. The USP <467> procedure using an autosampler configured with a gas tight syringe for static headspace sampling together with a Gas Chromatograph/Flame Ionization Detector (GC/FID) to a headspace sampling system. During the synthesis of some pharmaceuticals it is sometimes necessary to use solvents in order to increase the yield or purity of the product. After the pharmaceutical is produced, the solvent(s) are removed to the greatest extent possible.
United States Pharmacopeia (USP) general chapter <467> describes a static headspace gas chromatography procedure for the determination of residual solvents. This application will demonstrate the USP <467> procedure using an autosampler configured with a gas tight syringe for static headspace sampling.
Our Impact
EST Analytical has been helping labs achieve their analytical goals for over 30 years. Our vision is to engineer reliable laboratory instruments that enable partners to make the world a better place.
To help labs excel we offer Application Notes across our entire product line. They are a resource that explains the technology, performance, and abilities of our products as used against certain methodologies and or applications.
Whether your needs center around a USEPA method, an ASTM Standard, or a sample matrix-based outcome EST has you covered. If you don’t see the technical direction you need, simply contact us. We also offer sample analysis in our onsite Applications Lab.
